OncoACP3 | ACP3 ligand | Probechem Biochemicals

Chemical Structure : OncoACP3

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OncoACP3 (ProX1-(SS))

货号: PC-24851Not For Human Use, Lab Use Only.

OncoACP3 (ProX1-(SS)) is a specific small ligand of prostatic acid phosphatase (ACP3, ACPP, PAP, PAcP) with picomolar binding affinity, shows high selectivity over placental alkaline phosphatase, TNAP and human and murine serum albumins.

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生物&药学活性

OncoACP3 (ProX1-(SS)) is a specific small ligand of prostatic acid phosphatase (ACP3, ACPP, PAP, PAcP) with picomolar binding affinity, shows high selectivity over placental alkaline phosphatase, TNAP and human and murine serum albumins.
When radiolabelled with lutetium-177, OncoACP3 selectively accumulated in enzyme-expressing tumours with a long residence time (biological half-life greater than 72 h) and a high tumour-to-blood ratio (>148 at 2 h after administration).
OncoACP3 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) facilitated tumour-selective payload deposition, resulting in potent anti-tumour activity.
OncoACP3 is an ideal candidate for the delivery of diagnostic and therapeutic payloads to tumours.

物理化学性质&存储条件

分子量	822.95
分子式	C44H55N8O6P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((4-((1-((3S,5S)-5-((6-aminohexyl)carbamoyl)-1-(dibenzylglycyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)(benzylamino)methyl)phosphonic acid

参考文献

1. Georgiev T, et al. Nat Biomed Eng. 2025 Jun 26. doi: 10.1038/s41551-025-01432-6.

OncoACP3 (ProX1-(SS))

生物&药学活性

物理化学性质&存储条件

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OncoACP3 (ProX1-(SS))

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物理化学性质&存储条件

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