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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-Olvanil
Olvanil

Chemical Structure : Olvanil

CAS No.: 58493-49-5

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Olvanil (NE-19550, N-Vanillyloleamide)

货号: PC-25855Not For Human Use, Lab Use Only.

Olvanil (NE-19550, N-Vanillyloleamide) is a potent, selective agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with EC50 of 0.7 nM.

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50 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Olvanil (NE-19550, N-Vanillyloleamide) is a potent, selective agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with EC50 of 0.7 nM.
Olvanil inhibited [(3)H]Resiniferatoxin (RTX) binding to HEK293/VR1 cells with Ki of 0.4 uM.
Olvanil desensitizes nociceptors and alleviates pain.

物理化学性质&存储条件

分子量 417.63
分子式 C26H43NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Hydroxy-3-methoxybenzyl)oleamide

参考文献

1. Long DJ, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):525-30.

2. Savidge J, et al. Neuropharmacology. 2002 Sep;43(3):450-6.

3. Szallasi A, et al. Mol Pharmacol. 1999 Sep;56(3):581-7.

4. Lee MG, et al. Br J Pharmacol. 2005 Oct;146(4):596-603.

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