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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Olomoucine
Olomoucine

Chemical Structure : Olomoucine

CAS No.: 101622-51-9

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Olomoucine (CDK inhibitor)

货号: PC-60188Not For Human Use, Lab Use Only.

Olomoucine is a potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase.

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2 mg ￥880 In stock
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Olomoucine is a potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase.
Olomoucine also inhibits ERK1/MAP kinase (IC50=25 uM).
Olomoucine inhibits the starfish oocyte G2/M transition in vivo.

物理化学性质&存储条件

分子量 298.35
分子式 C15H18N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-Hydroxyethylamino)-6- benzylamino-9-methylpurine

参考文献

1. Veselý J, et al. Eur J Biochem. 1994 Sep 1;224(2):771-86.

2. Tsou YC, et al. Neurosci Lett. 2016 Aug 15;628:186-93.

3. Fei XF, et al. Brain Res. 2009 Apr 6;1264:85-97.

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