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首页-抗体和重组蛋白-Biosimilar Antibody-Oleclumab
Oleclumab

Chemical Structure : Oleclumab

CAS No.: 1803176-05-7

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Oleclumab (Anti-human CD73 mAb, human IgG1 K97R/L234F/L235E/P331S-Lambda2; MEDI9447)

货号: PC-Ab1032Not For Human Use, Lab Use Only.

Oleclumab (MEDI 9447) is a human IgG1 lambda mAb with a triple mutation in the heavy chain constant region for reduced effector function. Oleclumab binds to cluster of differentiation 73 (ecto-5'-nucleotidase) (CD73) and inhibits CD73-associated ectonucleotidase activity, thereby inhibiting the CD73-mediated production of immunosuppressive adenosine. Extracellular adenosine contributes to the immunosuppressive effects of both regulatory T cells and myeloid derived suppressor cells, among others.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Oleclumab (MEDI 9447) is a human IgG1 lambda mAb with a triple mutation in the heavy chain constant region for reduced effector function. Oleclumab binds to cluster of differentiation 73 (ecto-5'-nucleotidase) (CD73) and inhibits CD73-associated ectonucleotidase activity, thereby inhibiting the CD73-mediated production of immunosuppressive adenosine. Extracellular adenosine contributes to the immunosuppressive effects of both regulatory T cells and myeloid derived suppressor cells, among others. This, in turn, leads to increased antitumor immunity.

物理化学性质&存储条件

分子量
分子式 Human IgG1 K97R/L234F/L235E/P331S-Lambda2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Oleclumab; MEDI9447; MEDI 9447; MEDI-9447; 1803176-05-7; cluster of differentiation 73; ecto-5'-nucleotidase; CD73

参考文献

1. 1, Hay CM, et al. Oncoimmunology. 2016 Jul 11;5(8):e1208875. 2, Geoghegan JC,et al. MAbs. 2016;8(3):454-67. 3, De Caluwé A, et al. BMC Cancer. 2021 Aug 6;21(1):899.

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