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首页-抗体和重组蛋白-Biosimilar Antibody-Ofatumumab
Ofatumumab

Chemical Structure : Ofatumumab

CAS No.: 679818-59-8

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Ofatumumab (Anti-human CD20 mAb, human IgG1-Kappa; GSK-1841157; HuMax CD20)

货号: PC-Ab1110Not For Human Use, Lab Use Only.

Ofatumumab (GSK-1841157, OMB157) is a fully humanized, high-affinity monoclonal antibody whose epitope on CD20 is distinct from rituximab’s target. Ofatumumab induces efficient complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity, even when CD20 expression is low. Ofatumumab inhibits early-stage B lymphocyte activation..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ofatumumab (GSK-1841157, OMB157) is a fully humanized, high-affinity monoclonal antibody whose epitope on CD20 is distinct from rituximab’s target. Ofatumumab induces efficient complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity, even when CD20 expression is low. Ofatumumab inhibits early-stage B lymphocyte activation.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Ofatumumab; Arzerra; GSK-1841157; HuMax CD20; Kesimpta; OMB-157; 679818-59-8; Anti-human CD20; cluster of differentiation 20.

参考文献

1. 1, Du J, et al. Mol Immunol. 2009 Jul;46(11-12):2419-23. 2, Coiffier B, et al. Blood. 2008 Feb 1;111(3):1094-100. 3, Nightingale G. Ann Pharmacother. 2011 Oct;45(10):1248-55. 4, Herter S, et al. Mol Cancer Ther. 2013 Oct;12(10):2031-42.

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