Ocadusertib (LY3871801, R552) | RIPK1 inhibitor | Probechem Biochemicals

Chemical Structure : Ocadusertib

CAS No.: 2382811-41-6

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Ocadusertib (LY3871801, R 552)

货号: PC-24972Not For Human Use, Lab Use Only.

Ocadusertib (LY3871801, R552) is a potent and selective, allosteric inhibitor of RIPK1 with IC50 of 12-38 nM.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

Ocadusertib (LY3871801, R552) is a potent and selective, allosteric inhibitor of RIPK1 with IC50 of 12-38 nM.
Ocadusertib inhibits necroptotic responses in multiple in vitro immortalized and primary cell-based assays with a potency of 0.4 to 3 nM.
Ocadusertib inhibits TNF/zVAD-induced cell death with a potency of 7 to 9 nM in human whole blood assays.
Ocadusertib shows no significant inhibition in a panel of 105 kinases at 10 uM.
Ocadusertib prevents RIPK1-dependent hypothermia in response to a TNF challenge; inhibits necroptosis-induced skin inflammation in an acute model; and is efficacious in a chronic proliferative dermatitis (Sharpincpdm) model.

物理化学性质&存储条件

分子量	459.51
分子式	C25H25N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-benzyl-N-(7-(3-hydroxy-3-methylbut-1-yn-1-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-3-carboxamide

参考文献

1. Eric Hanson, et al. ACR Convergence 2024.

Ocadusertib (LY3871801, R 552)

生物&药学活性

物理化学性质&存储条件

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Ocadusertib (LY3871801, R 552)

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物理化学性质&存储条件

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