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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-OXF-077
OXF-077

Chemical Structure : OXF-077

CAS No.:

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OXF-077 (OXF077)

货号: PC-22567Not For Human Use, Lab Use Only.

OXF-077 is a potent inhibitor of the mutagenic SOS response, suppresses the rate of ciprofloxacin resistance emergence in S. aureus, is a potentiator of DNA-damage in MRSA, directly targets signal peptidase IB (SpsB).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    OXF-077 is a potent inhibitor of the mutagenic SOS response, suppresses the rate of ciprofloxacin resistance emergence in S. aureus, is a potentiator of DNA-damage in MRSA, directly targets signal peptidase IB (SpsB).

    物理化学性质&存储条件

    分子量 536.55
    分子式 C25H24F4N4O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-fluoro-1-isopropyl-4-oxo-7-(4-((4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

    参考文献

    1. Bradbury JD, et al. Chem Sci. 2024 May 16;15(25):9620-9629.
    2. Bradbury JD, et al. Cell Chem Biol. 2026 May 20:S2451-9456(26)00149-2.

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