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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-OUL312
OUL312

Chemical Structure : OUL312

CAS No.:

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OUL312 (OUL-312)

货号: PC-25415Not For Human Use, Lab Use Only.

OUL312 (OUL-312) is a potent, selective PARP10 inhibitor with IC50 of 20 nM, 75-fold selectivity over PARP15 (IC50=1500 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

OUL312 (OUL-312) is a potent, selective PARP10 inhibitor with IC50 of 20 nM, 75-fold selectivity over PARP15 (IC50=1500 nM).
OUL312 displays 18-fold selectivity over PARP11 (IC50=360 nM), little to no activity against all the poly-ARTs enzymes as well as for PARP3 and PARP4.
OUL312 rescues cells from PARP10-induced apoptosis with EC50 of <1 uM.

物理化学性质&存储条件

分子量 300.29
分子式 C16H13FN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-[2-(2-fluorophenyl)ethoxy]-1,2,3,4-tetrahydrophthalazine-1,4-dione

参考文献

1. Alaviuhkola J, et al. Eur J Med Chem. 2025 Sep 1;300:118111.

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