OTS514 | PBK/TOPK inhibitor | Probechem Biochemicals

Chemical Structure : OTS514

CAS No.: 1338540-63-8

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OTS514 (OTS-514)

货号: PC-45487Not For Human Use, Lab Use Only.

OTS514 (OTS-514) is a highly potent and selective inhibitor of T-lymphokine-activated killer-cell-originated protein kinase (TOPK, PDZ-binding kinase/PBK) with IC50 of 2.6 nM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

OTS514 (OTS-514) is a highly potent and selective inhibitor of T-lymphokine-activated killer-cell-originated protein kinase (TOPK, PDZ-binding kinase/PBK) with IC50 of 2.6 nM.
OTS514 shows selectivity against a panel of 60 kinases (at 0.2 uM, 11.5-18.5% inhibition).
OTS514 strongly suppresses the growth of TOPK-positive cancer cells.
OTS514 demonstrates in vivo efficacy but causes severe hematopoietic toxicity.

物理化学性质&存储条件

分子量	364.4607
分子式	C21H20N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thieno[2,3-c]quinolin-4(5H)-one, 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-

参考文献

1. Matsuo Y, et al. Sci Transl Med. 2014 Oct 22;6(259):259ra145.

2. Alachkar H, et al. Oncotarget. 2015 Oct 20;6(32):33410-25.

3. Kato T, et al. Oncotarget. 2016 Apr 5;7(14):17652-64.

OTS514 (OTS-514)

生物&药学活性

物理化学性质&存储条件

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OTS514 (OTS-514)

生物&药学活性

物理化学性质&存储条件

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