ORS-22 | LILRB4/ILT3 ligand | Probechem Biochemicals

Chemical Structure : ORS-22

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ORS-22 (ORS22)

货号: PC-28169Not For Human Use, Lab Use Only.

ORS-22 is a high affinity small molecule direct ligand of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) with MST KD of 9.2 nM, binds LILRB4 extracellular domain.

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生物&药学活性

ORS-22 is a high affinity small molecule direct ligand of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) with MST KD of 9.2 nM, binds LILRB4 extracellular domain.
ORS-22 produces a robust dose-dependent increase in thermally stabilized soluble LILRB4 with EC50 of 33.5 nM in cellular thermal shift assay (CETSA) assays.
ORS-22 restores anti-tumor immune activity across colorectal cancer and AML co-culture systems.
ORS-22 can phenocopy the effects of anti-LILRB4 antibody blockade across multiple orthogonal functional readouts strongly supports an on-target mechanism of action.
ORS-22 is capable of reversing SCG2-driven immunosuppression and restoring productive immune activity in clinically relevant human tumor co-culture systems.

物理化学性质&存储条件

分子量	342.42
分子式	C16H18N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(benzo[d]thiazol-2-yl(methyl)amino)-1-(3-methyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)ethan-1-one

参考文献

1. Abdel-Rahman SA, et al. Bioorg Med Chem Lett. 2026 Nov;140:130717.

ORS-22 (ORS22)

生物&药学活性

物理化学性质&存储条件

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ORS-22 (ORS22)

生物&药学活性

物理化学性质&存储条件

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