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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Immune Checkpoints-ORS-14
ORS-14

Chemical Structure : ORS-14

CAS No.: 1311892-52-0

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ORS-14 (ORS14)

货号: PC-28168Not For Human Use, Lab Use Only.

ORS-14 is a high affinity small molecule direct ligand of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) with MST KD of 85.2 nM, binds LILRB4 extracellular domain.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ORS-14 is a high affinity small molecule direct ligand of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) with MST KD of 85.2 nM, binds LILRB4 extracellular domain.
ORS-14 restores anti-tumor immune activity across colorectal cancer and AML co-culture systems.
ORS-14 is capable of reversing SCG2-driven immunosuppression and restoring productive immune activity in clinically relevant human tumor co-culture systems. 

物理化学性质&存储条件

分子量 323.36
分子式 C17H17N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((2-(3,4-dimethylphenoxy)pyridin-4-yl)methyl)-1H-1,2,3-triazole-4-carboxamide

参考文献

1. Abdel-Rahman SA, et al. Bioorg Med Chem Lett. 2026 Nov;140:130717.

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