OPC-33540 | PDE3 inhibitor | Probechem Biochemicals

Chemical Structure : OPC-33540

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OPC-33540 (OPC33540)

货号: PC-28251Not For Human Use, Lab Use Only.

OPC-33540 (OPC33540) is a potent, highly selective and competitive PDE3 inhibitor with IC50 of 0.32 nM and 1.5 nM for PDE3A and PDE3AB respectively.

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生物&药学活性

OPC-33540 (OPC33540) is a potent, highly selective and competitive PDE3 inhibitor with IC50 of 0.32 nM and 1.5 nM for PDE3A and PDE3AB respectively.
OPC-33540 displays little to no activity against PDE1, PDE2, PDE4, PDE5, and PDE7.
OPC-33540 potentiates cyclic AMP accumulation concentration-dependently in both the absence and the presence of 3 nM prostaglandin E1 (PGE1) (doubling concentrations: 32.5 and 6.2 nM, respectively) in platelets.
OPC-33540 inhibits thrombin-induced platelet aggregation with IC50 of 27.8 nM.
OPC-33540 inhibits anti-platelet aggregation effect stimulated in the presence of 3 nM PGE1 with IC50 of 6.0 nM.

物理化学性质&存储条件

分子量	469.63
分子式	C27H39N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-cyclooctyl-N′-[3-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]propyl]-N-[(1R,2R)-2-hydroxycyclohexyl]-, rel-

参考文献

1. Sudo T, et al. Biochem Pharmacol 2000, 59: 347–356.

OPC-33540 (OPC33540)

生物&药学活性

物理化学性质&存储条件

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OPC-33540 (OPC33540)

生物&药学活性

物理化学性质&存储条件

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