ONL1204 | Fas receptor inhibitor | Probechem Biochemicals

Chemical Structure : ONL1204

CAS No.: 2040964-58-5

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ONL1204 (ONL-1204, Xelafaslatide)

货号: PC-24946Not For Human Use, Lab Use Only.

ONL1204 (Xelafaslatide) is a small peptide inhibitor of the Fas receptor, blocks Fas death receptor signaling and prevents mFasL-induced apoptosis.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ONL1204 (Xelafaslatide) is a small peptide inhibitor of the Fas receptor, blocks Fas death receptor signaling and prevents mFasL-induced apoptosis.
ONL1204 rescues A20 B lymphoma cells from FasL-mediated apoptosis.
ONL1204 protects RGCs and prevents axon degeneration in the microbead-induced model of glaucoma.
ONL1204 shows protective effect in distinct mouse models of retinal degeneration.

物理化学性质&存储条件

分子量	1461.69
分子式	C71H100N18O16
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Tyrosinamide, L-histidyl-L-histidyl-L-isoleucyl-L-tyrosyl-L-leucylglycyl-L-alanyl-L-valyl-L-asparaginyl-L-tyrosyl-L-isoleucyl-

参考文献

1. Krishnan A, et al. J Neuroinflammation. 2019 Sep 30;16(1):184.

2. Yang M, et al. Cell Death Dis. 2024 Aug 8;15(8):576.

ONL1204 (ONL-1204, Xelafaslatide)

生物&药学活性

物理化学性质&存储条件

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ONL1204 (ONL-1204, Xelafaslatide)

生物&药学活性

物理化学性质&存储条件

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