OICR-41103 | DCAF1 ligand | Probechem Biochemicals

Chemical Structure : OICR-41103

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OICR-41103 (OICR41103)

货号: PC-25147Not For Human Use, Lab Use Only.

OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein.

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生物&药学活性

OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein.
shows no affinity for a panel of six WDR proteins up to 20 uM.
OICR-41103 binds and engages the WDR domain of DCAF1 in cells, effectively thermally stabilized the WDR domain of DCAF1 with EC50 of 165 nM.
OICR-41103 displaces HIV viral accessory protein Vpr from the DCAF1 WDR domain.

物理化学性质&存储条件

分子量	575.44
分子式	C28H26Cl2F2N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-N-(3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl)-4-(4-chloro-2-fluorophenyl)-5-(3-oxo-3-(piperidin-1-yl)prop-1-en-1-yl)-1H-pyrrole-3-carboxamide

参考文献

1. Kimani SW, et al. Commun Biol. 2025 Jul 19;8(1):1076.

OICR-41103 (OICR41103)

生物&药学活性

物理化学性质&存储条件

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OICR-41103 (OICR41103)

生物&药学活性

物理化学性质&存储条件

参考文献

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