Nutlin-3a |CAS:675576-98-4 Probechem Biochemicals

Chemical Structure : Nutlin-3a

CAS No.: 675576-98-4

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Nutlin-3a (Rebemadlin)

货号: PC-42100Not For Human Use, Lab Use Only.

Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
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生物&药学活性

Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.
Nutlin-3a blocks the binding of Mdm2 to key signaling molecules such as p53 and p73α and can result in activation of cell death signaling pathways.

物理化学性质&存储条件

分子量	581.4896
分子式	C30H30Cl2N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-

参考文献

1. Vassilev LT, et al. Science, 2004, 303(5659), 844-848.

2. Schneider LS, et al. Mol Oncol. 2016 Aug;10(7):1054-62.

3. Tonsing-Carter E, et al. Mol Cancer Ther. 2015 Dec;14(12):2850-63.

Nutlin-3a (Rebemadlin)

生物&药学活性

物理化学性质&存储条件

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Nutlin-3a (Rebemadlin)

生物&药学活性

物理化学性质&存储条件

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