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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Nur77 (NR4A1)-Nur77 modulator 1
Nur77 modulator 1

Chemical Structure : Nur77 modulator 1

CAS No.: 2469975-55-9

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Nur77 modulator 1 (Compound10g)

货号: PC-26966Not For Human Use, Lab Use Only.

Nur77 modulator 1 is a high affintiy Nur77 modulator (KD = 3.58 uM), up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis, shows broad-spectrum antiproliferative activity against hepatoma cells with IC50 of >2.0 uM.

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2880 In stock
25 mg ￥4980 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nur77 modulator 1 is a high affintiy Nur77 modulator (KD = 3.58 uM), up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis, shows broad-spectrum antiproliferative activity against hepatoma cells with IC50 of >2.0 uM.

物理化学性质&存储条件

分子量 495.60
分子式 C28H25N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-5-((8-Methoxy-2-methylquinolin-4-yl)amino)-N'-(4-(methylthio)benzylidene)-1H-indole-2-carbohydrazide

参考文献

1. Baicun Li, et al. Eur J Med Chem. 2020 Oct 15;204:112608.

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