Np75-4A22

Chemical Structure : Np75-4A22

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货号: PC-25545Not For Human Use, Lab Use Only.

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生物&药学活性

Np75-4A22 is a specific small molecule inhibitor of the transmembrane domain of death receptor p75NTR (p75NTR TMD), antagonizes NGF-mediated recruitment of the actin-bundling protein fascin to p75NTR, inhibits the migration and lung invasion of human melanoma cells in mice.
Np75-4A22 (1 uM) blocked all NGF activity in Boyden chamber assay of cell chemotaxis.
Np75-4A22 significantly reduced NGF-induced A875 chemotaxis at submicromolar concentrations.
Np75-4A22 inhibited melanoma cell invasion at submicromolar concentrations without inducing cell death.
Np75-4A22 blocked NGF-mediated recruitment of fascin to p75NTR, NGF-induced fascin association with the cytoskeleton and NGF-stimulated filopodia formation.
Np75-4A22 (orally at 200 mg/kg) reduced the spread and seeding of melanoma lung tumors in a mouse xenograft model.

物理化学性质&存储条件

分子量	423.14
分子式	C18H14BrCl2N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromo-2,3-dichlorophenyl)-6-(2,3-dimethylphenyl)pyrazin-2-amine

参考文献

1. Lopes-Rodrigues V, et al. EMBO Mol Med. 2025 Sep 17. doi: 10.1038/s44321-025-00297-1.

Np75-4A22

生物&药学活性

物理化学性质&存储条件

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Np75-4A22

生物&药学活性

物理化学性质&存储条件

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