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首页-抗体和重组蛋白-Biosimilar Antibody-Nivolumab
Nivolumab

Chemical Structure : Nivolumab

CAS No.: 946414-94-4

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Nivolumab (Anti-human PD-1 mAb, human IgG4 (S228P)-Kappa)

货号: PC-Ab1008Not For Human Use, Lab Use Only.

Nivolumab binds to the extracellular portion of human PD-1 (2.6 nM - Scatchard analysis and SPR) - the antibody also binds to cynomolgus PD-1 with a similar affinity (3.9 nM - SPR). The antibody does not bind to other immunoglobulin superfamily proteins such as CD28, CTLA-4, ICOS and BTLA. Nivolumab enhances immune response against various cancers. .

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10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nivolumab binds to the extracellular portion of human PD-1 (2.6 nM - Scatchard analysis and SPR) - the antibody also binds to cynomolgus PD-1 with a similar affinity (3.9 nM - SPR). The antibody does not bind to other immunoglobulin superfamily proteins such as CD28, CTLA-4, ICOS and BTLA. Nivolumab enhances immune response against various cancers.

物理化学性质&存储条件

分子量
分子式 Human IgG4 (S228P)-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Nivolumab; OPDIVO; BMS-936558; MDX-1106;CD279; programmed death-1; programmed death 1 ; PD1; PD 1; Programmed cell death protein 1; hPD-1; hPD1; hPD 1; BMS-936558; MDX-1106;ONO-4538

参考文献

1. 1, Wolchok JD, et al. N Engl J Med. 2013 Jul 11;369(2):122-33. 2, Homet Moreno B, et al. Br J Cancer. 2015 Apr 28;112(9):1421-7. 3, Fu J, et al. Cancer Res. 2014 Aug 1;74(15):4042-52.

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