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Nivegacetor

Chemical Structure : Nivegacetor

CAS No.: 2443487-67-8

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Nivegacetor (RG6289, RG-6289)

货号: PC-24970Not For Human Use, Lab Use Only.

Nivegacetor (RG6289) is a novel, potent and selective, orally bioavailable γ-secretase modulator (GSM), induces a dose‐dependent shift in the production of longer (Aβ40 and Aβ42) and shorter (Aβ37 and Aβ38) Aβ monomers in serial cerebrospinal fluid (CSF).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Nivegacetor (RG6289) is a novel, potent and selective, orally bioavailable γ-secretase modulator (GSM), induces a dose‐dependent shift in the production of longer (Aβ40 and Aβ42) and shorter (Aβ37 and Aβ38) Aβ monomers in serial cerebrospinal fluid (CSF).

物理化学性质&存储条件

分子量 469.50
分子式 C23H25F2N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-7-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-methoxypyridazin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine

参考文献

1. Thomas Mueggler, et al. Alzheimers Dement. 2025 Jan 9;20(Suppl 8):e095213.

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