Nardilysin inhibitor R5-1

Chemical Structure : Nardilysin inhibitor R5-1

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货号: PC-28094Not For Human Use, Lab Use Only.

Nardilysin inhibitor R5-1 is a small-molecule inhibitor of nardilysin (NRDC), inhibits NRDC activity in a non-competitive manner, attenuates NRDC-dependent transcriptional repression of PGC-1α, phenocopying the effect of catalytic inactivation, significantly ameliorates arthritis severity in mouse model of autoimmune arthritis.

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

Nardilysin inhibitor R5-1 is a small-molecule inhibitor of nardilysin (NRDC), inhibits NRDC activity in a non-competitive manner, attenuates NRDC-dependent transcriptional repression of PGC-1α, phenocopying the effect of catalytic inactivation, significantly ameliorates arthritis severity in mouse model of autoimmune arthritis.

物理化学性质&存储条件

分子量	234.27
分子式	C11H10N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(quinoxalin-2-ylthio)propanoic acid

参考文献

1. Amano Y, et al. Biochem Pharmacol. 2026 Sep 9:118456.