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首页-抗体和重组蛋白-Biosimilar Antibody-Naptumomab
Naptumomab

Chemical Structure : Naptumomab

CAS No.: 676258-98-3

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Naptumomab (Anti-human 5T4 mAb, human IgG1-Kappa)

货号: PC-Ab1027Not For Human Use, Lab Use Only.

Naptumomab is a fusion protein containing the Fab-fragment of an antibody that targets the tumor-associated 5T4 antigen. Naptumomab activates T lymphocytes and targets them to the 5T4-expressing tumors, resulting in massive effector lymphocyte infiltration into the tumor and tumor cell killing. 5T4 (trophoblast glycoprotein, TPBG) is a transmembrane tumor antigen expressed on more than 90% of primary renal cell carcinomas (RCC) and a wide range of human carcinomas but not on most somatic adult t

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Naptumomab is a fusion protein containing the Fab-fragment of an antibody that targets the tumor-associated 5T4 antigen. Naptumomab activates T lymphocytes and targets them to the 5T4-expressing tumors, resulting in massive effector lymphocyte infiltration into the tumor and tumor cell killing. 5T4 (trophoblast glycoprotein, TPBG) is a transmembrane tumor antigen expressed on more than 90% of primary renal cell carcinomas (RCC) and a wide range of human carcinomas but not on most somatic adult tissues.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Naptumomab; Naptumomab Estafenatox; 5T4 antigen; 676258-98-3; 5T4FabV18-SEA/E-120); ABR-217620; Trophoblast glycoprotein; TPBG; 5T4 oncofoetal antigen

参考文献

1. 1, Baoying Shi, et al. Cancer Med. 2019 Apr; 8(4): 1793–1805. 2, Hedlund G, et al. PLoS One. 2013 Oct 23;8(10):e79082.  3, Eisen T, et al. Curr Oncol Rep. 2014 Feb;16(2):370. 

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