Nanaomycin A

Chemical Structure : Nanaomycin A

CAS No.: 52934-83-5

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货号: PC-26866Not For Human Use, Lab Use Only.

Nanaomycin A is a quinone antibiotics and selective DNA methyltransferase DNMT3B inhibitor with IC50 of 500 nM.

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5 mg	￥3280	In stock
5 mg	￥5280	In stock
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生物&药学活性

Nanaomycin A is a quinone antibiotics and selective DNA methyltransferase DNMT3B inhibitor with IC50 of 500 nM.
Nanaomycin A inhibits the biosyntheses of protein, DNA, RNA and cell-well peptidoglycan on Gram-positive such as Staphylococcus aureaus, Bacillus cereus and Streptococcus faecalis.
Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with IC50 of 33.1 nM.
Nanaomycin A potently inhibits cell viability of HCT116 (colon), A549 (lung), and HL60 (bone marrow) with IC50 of 0.4 uM, 4.1 uM and 0.8 uM respectively.

物理化学性质&存储条件

分子量	302.28
分子式	C16H14O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1S,3R)-9-hydroxy-1-methyl-5,10-dioxo-3,4,5,10-tetrahydro-1H-benzo[g]isochromen-3-yl)acetic acid

参考文献

1. Kuck D, et al. Mol Cancer Ther. 2010 Nov;9(11):3015-23.

2. Marumo H, et al. J Antibiot (Tokyo). 1980 Aug;33(8):885-90.

3. Tanaka Y, et al. J Antibiot (Tokyo). 1999 Oct;52(10):880-8.

Nanaomycin A

生物&药学活性

物理化学性质&存储条件

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Nanaomycin A

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