Nacubactam | β-lactamase inhibitor Probechem Biochemicals

Chemical Structure : Nacubactam

CAS No.: 1452458-86-4

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Nacubactam (OP0595, RG6080, RO 7079901)

货号: PC-62613Not For Human Use, Lab Use Only.

Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5580	In stock
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生物&药学活性

Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial.
Nacubactam exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2.
Nacubactam has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp.
Nacubactam increases the antibacterial activity of cefepime in both in vitro and in vivo.

物理化学性质&存储条件

分子量	324.31
分子式	C9H16N4O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S, 5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

参考文献

1. Morinaka A, et al. J Antimicrob Chemother. 2015 Oct;70(10):2779-86.

2. Livermore DM, et al. J Antimicrob Chemother. 2015 Nov;70(11):3032-41.

3. Livermore DM, et al. Antimicrob Agents Chemother. 2015 Nov 9;60(1):554-60.

4. Morinaka A, et al. J Antibiot (Tokyo). 2017 Mar;70(3):246-250.

Nacubactam (OP0595, RG6080, RO 7079901)

生物&药学活性

物理化学性质&存储条件

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Nacubactam (OP0595, RG6080, RO 7079901)

生物&药学活性

物理化学性质&存储条件

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