NYY-001 | GSNOR inhibitor | Probechem Biochemicals

Chemical Structure : NYY-001

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NYY-001 (NYY001)

货号: PC-25979Not For Human Use, Lab Use Only.

NYY-001 is a specific small molecule S-nitrosoglutathione reductase (GSNOR) inhibitor, selectively blocks the GSNOR-ERG (ETS-related gene) interaction, enhancespostischemic neovascularization and restored vascular permeability in the peripheral vasculature in STZ-induced type 1 diabetes and db/db type 2 diabetes mouse models.

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生物&药学活性

NYY-001 is a specific small molecule S-nitrosoglutathione reductase (GSNOR) inhibitor, selectively blocks the GSNOR-ERG (ETS-related gene) interaction, enhancespostischemic neovascularization and restored vascular permeability in the peripheral vasculature in STZ-induced type 1 diabetes and db/db type 2 diabetes mouse models.

物理化学性质&存储条件

分子量	499.59
分子式	C27H25N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-(1H-imidazol-1-yl)phenyl)-5-(3-oxo-3-(2-oxothiazolidin-3-yl)propyl)-1H-pyrrol-1-yl)-3-methylbenzamide

参考文献

1. Zhao S, et al. Sci Transl Med. 2025 Oct;17(818):eadn9216.

NYY-001 (NYY001)

生物&药学活性

物理化学性质&存储条件

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NYY-001 (NYY001)

生物&药学活性

物理化学性质&存储条件

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