NXPZ-2 | Keap1-Nrf2 inhibitor | Probechem Biochemicals

Chemical Structure : NXPZ-2

CAS No.: 2254492-08-3

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NXPZ-2 (NXPZ2)

货号: PC-28167Not For Human Use, Lab Use Only.

NXPZ-2 is a potent, direct, non-covalent inhibitor of Keap1-Nrf2 protein-protein interaction with Ki of 95 nM in FP assays and EC50 of 120 nM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

NXPZ-2 is a potent, direct, non-covalent inhibitor of Keap1-Nrf2 protein-protein interaction with Ki of 95 nM in FP assays and EC50 of 120 nM.
NXPZ-2 improves AD mice cognitive function on spatial learning and memory function in Aβ-induced AD mice using Morris water maze.
NXPZ-2 rescues the brain structure damage of AD mice with no obvious toxicity.
NXPZ-2 activates Nrf2 and decreases oxidative stress in AD mice.
NXPZ-2 decreases AD marker protein expression levels, with no effect on the Nrf2 knockout AD mouse model.

物理化学性质&存储条件

分子量	597.66
分子式	C27H27N5O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((N-(4-((4-Amino-N-(2-amino-2-oxoethyl)phenyl)sulfonamido)naphthalen-1-yl)-4-methoxyphenyl)sulfonamido)acetamide

参考文献

1. Sun Y, et al. Bioorg Chem. 2020 Oct;103:104172.

2. Sun Y, et al. Redox Biol. 2023 Aug;64:102793.

NXPZ-2 (NXPZ2)

生物&药学活性

物理化学性质&存储条件

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NXPZ-2 (NXPZ2)

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