NWL-117 | Caspase-6 inhibitor | ProbeChem Biochemicals

Chemical Structure : NWL-117

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NWL-117 (NWL117, NWL 117)

货号: PC-70208Not For Human Use, Lab Use Only.

NWL-117 is a potent, BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.

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生物&药学活性

NWL-117 is a potent, BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.
NWL-117 shows weak activity against other Capase subutypes.
NWL-117 inhibits Caspase-6 in Caspase-6-transfected HCT116 cells with IC50 of 4.82 uM.
NWL-117 inhibits serum deprivation-induced Caspase-6 activity and prevents amyloid precursor protein-mediated neurite degeneration in human primary CNS neurons.

物理化学性质&存储条件

分子量	654.732
分子式	C29H42N4O11S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5S,8S,11S,14R)-11-((S)-sec-butyl)-8-(2-carboxyethyl)-5-isopropyl-14-((E)-2-(methylsulfonyl)vinyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazapentadecan-15-oic acid

参考文献

1. Pakavathkumar P, et al. Mol Neurodegener. 2017 Feb 28;12(1):22.

NWL-117 (NWL117, NWL 117)

生物&药学活性

物理化学性质&存储条件

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NWL-117 (NWL117, NWL 117)

生物&药学活性

物理化学性质&存储条件

参考文献

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