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首页-抗体药物偶连体和PROTACs-PROTAC-NVS-VHL720
NVS-VHL720

Chemical Structure : NVS-VHL720

CAS No.:

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NVS-VHL720

货号: PC-25285Not For Human Use, Lab Use Only.

NVS-VHL720 is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 71 nM, binds with VHL (binary) with SPR KD of 72 nM, induces CDO1 degradation (absDC50 of 8 nM/98% degradation) in HEK293T cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NVS-VHL720 is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 71 nM, binds with VHL (binary) with SPR KD of 72 nM, induces CDO1 degradation (absDC50 of 8 nM/98% degradation) in HEK293T cells.

物理化学性质&存储条件

分子量 477.57
分子式 C26H31N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,4R)-N-((4-(3H-pyrazol-4-yl)naphthalen-1-yl)methyl)-1-(acetyl-L-valyl)-4-hydroxypyrrolidine-2-carboxamide

参考文献

1. Tutter A, et al. Nat Chem Biol. 2025 Jun 24. doi: 10.1038/s41589-025-01936-x.

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