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首页-抗体药物偶连体和PROTACs-PROTAC-NVS-VHL097
NVS-VHL097

Chemical Structure : NVS-VHL097

CAS No.: 1448188-69-9

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NVS-VHL097 (VL285 Phenol)

货号: PC-25284Not For Human Use, Lab Use Only.

NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells.

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10 mg ￥980 In stock
25 mg ￥1480 In stock
100 mg ￥3480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells.

物理化学性质&存储条件

分子量 532.66
分子式 C29H32N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Tutter A, et al. Nat Chem Biol. 2025 Jun 24. doi: 10.1038/s41589-025-01936-x.

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