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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HBV-NVR 3-778
NVR 3-778

Chemical Structure : NVR 3-778

CAS No.: 1445790-55-5

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NVR 3-778 (NVR3-778, NVR 3778)

货号: PC-35873Not For Human Use, Lab Use Only.

NVR 3-778 (NVR3-778, NVR 3778) is a small molecule inhibitor of HBV replication that targets the viral core protein, a first-in-class capsid assembly modulator.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NVR 3-778 (NVR3-778, NVR 3778) is a small molecule inhibitor of HBV replication that targets the viral core protein, a first-in-class capsid assembly modulator.
NVR 3-778 inhibits the generation of infectious HBV DNA containing virus particles with EC50 of 0.40 uM in HepG2.2.15 cells.
NVR 3-778 inhibits pgRNA encapsidation, viral replication and the production of HBV DNA- and HBV RNA-containing particles.
NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50 of 0.81 uM against HBV DNA and 3.7-4.8 uM against the production of HBV antigens and intracellular HBV RNA.
NVR 3-778 demonstrates favorable pharmacokinetics and safety in animal species.

物理化学性质&存储条件

分子量 432.39
分子式 C18H16F4N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-fluoro-3-((4-hydroxypiperidin-1-yl)sulfonyl)-N-(3,4,5-trifluorophenyl)benzamide

参考文献

1. Lam AM, et al. Antimicrob Agents Chemother. 2018 Oct 29. pii: AAC.01734-18.

2. Klumpp K, et al. Gastroenterology. 2018 Feb;154(3):652-662.e8.

3. Helsen N, et al. Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01497-18.

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