NVP-TAE684 | ALK inhibitor | Probechem Biochemicals

Chemical Structure : NVP-TAE684

CAS No.: 761439-42-3

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NVP-TAE684 (TAE-684, TAE684)

货号: PC-42437Not For Human Use, Lab Use Only.

NVP-TAE 684 (TAE684) is a highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.

规格	价格	库存
5 mg	￥680	In stock
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

NVP-TAE 684 (TAE684) is a highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.
NVP-TAE 684 (TAE684) exhibits no significant cross-reactivity against other kinases.
NVP-TAE 684 (TAE684) blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 2-10 nM, inhibits phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.
NVP-TAE 684 (TAE684) suppresses lymphomagenesis in in vivo models.

物理化学性质&存储条件

分子量	614.2017
分子式	C30H40ClN7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Pyrimidinediamine, 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

参考文献

1. Galkin AV, et al. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5.

2. Katayama R, et al. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40.

3. George RE, et al. Nature. 2008 Oct 16;455(7215):975-8.

4. McDermott U, et al. Cancer Res. 2008 May 1;68(9):3389-95.

NVP-TAE684 (TAE-684, TAE684)

生物&药学活性

物理化学性质&存储条件

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NVP-TAE684 (TAE-684, TAE684)

生物&药学活性

物理化学性质&存储条件

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