欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-NVP-CGM097
NVP-CGM097

Chemical Structure : NVP-CGM097

CAS No.: 1313363-54-0

加入收藏

NVP-CGM097 (CGM097)

货号: PC-24496Not For Human Use, Lab Use Only.

NVP-CGM097 is potent and selective MDM2 inhibitor with Ki of 1.3 nM (human MDM2, HDM2), inhibits p53-MDM2 protein-protein interaction with IC50 of 1.7 nM in TR-FRET assays.

规格 价格 库存 数量
2 mg ￥580 In stock
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NVP-CGM097 is potent and selective MDM2 inhibitor with Ki of 1.3 nM (human MDM2, HDM2), inhibits p53-MDM2 protein-protein interaction with IC50 of 1.7 nM in TR-FRET assays.
NVP-CGM097 is 16-fold more potent on human than dog MDM2 and 51- and 37-fold more potent on human than mouse and rat MDM2, respectively.
NVP-CGM097 binds to human MDM2 with an IC50 of 1.7 nM and shows high selectivity over MDM4.
NVP-CGM097 is about four times more potent than Nutlin-3a (IC50 = 8.0 nM).
NVP-CGM097 significantly redistribute wild-type p53 into the cell nucleus with an IC50 of 0.224 μM.
NVP-CGM097 significantly inhibited the proliferation of cells expressing wild-type p53, while sparing the p53 null cells.
NVP-CGM097 dose dependently and significantly inhibited SJSA-1 tumor growth in rats.

物理化学性质&存储条件

分子量 659.27
分子式 C38H47ClN4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,4-dihydroisoquinolin-3(2H)-one

参考文献

1. Jeay S, et al. Elife. 2015 May 12;4:e06498.

2. Holzer P, et al. J Med Chem. 2015 Aug 27;58(16):6348-58.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: