NVP-BAW2881 |CAS:861875-60-7 Probechem Biochemicals

Chemical Structure : NVP-BAW2881

CAS No.: 861875-60-7

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NVP-BAW2881 (BAW2881;BAW-2881)

货号: PC-42130Not For Human Use, Lab Use Only.

NVP-BAW2881 is a potent, selective VEGFR inhibitor with IC50 of 37 nM for hVEGFR2 (KDR).

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25 mg	￥1880	In stock
100 mg	￥3880	In stock
200 mg	￥5880	In stock
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生物&药学活性

NVP-BAW2881 is a potent, selective VEGFR inhibitor with IC50 of 37 nM for hVEGFR2 (KDR).
NVP-BAW2881 also demonstrates activity against Tie2 (IC50=650 nM) and RET (IC50=410 nM), no activity against a wide panel of other kinases.
NVP-BAW2881 inhibits VEGF-A-induced phosphorylation of VEGFR-2 in HUVECs and in VEGFR-2-transfected CHO cells with IC50 of 2.9 and 4.2 nM, respectively.
NVP-BAW2881 also inhibits phosphorylation of RET, PDGFRβ and c-Kit with IC50 of 40-80 nM.
NVP-BAW2881 inhibits the proliferation, migration and tube formation by HUVECs and lymphatic endothelial cells in vitro.
NVP-BAW2881 displays strong anti-inflammatory effects in models of acute inflammation such as psoriasis.

物理化学性质&存储条件

分子量	424.3753
分子式	C22H15F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	1-Naphthalenecarboxamide, 6-[(2-amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-

参考文献

1. Halin C, et al. Am J Pathol. 2008 Jul;173(1):265-77.

NVP-BAW2881 (BAW2881;BAW-2881)

生物&药学活性

物理化学性质&存储条件

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NVP-BAW2881 (BAW2881;BAW-2881)

生物&药学活性

物理化学性质&存储条件

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