NVP-231 | CerK inhibitor | Probechem Biochemicals

Chemical Structure : NVP-231

CAS No.: 362003-83-6

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NVP-231 (NVP231, NVP 231)

货号: PC-20871Not For Human Use, Lab Use Only.

NVP-231 (NVP231) is a potent, specific, and reversible ceramide kinase (CerK) inhibitor with IC50 of 12 nM.

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100 mg	￥2980	In stock
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生物&药学活性

NVP-231 (NVP231) is a potent, specific, and reversible ceramide kinase (CerK) inhibitor with IC50 of 12 nM.
NVP-231 does not compete with ATP but rather with ceramide, displaying an inhibition constant (Ki) of 7.4 nM.
NVP-231 inhibits C1P formation with IC50 of <10 nM in human CerK-overexpressing COS-cells (COS-CerK), achieved complete inhibition at 100 nM.
NVP-231 also is a potent inhibitor of mouse CerK.
NVP-231 does not inhibit sphingosine kinases and other lipid kinases, including phosphatidylinositol-3 kinase, phosphatidylinositol-4 kinase β, and Vps34.
When combined with another ceramide metabolizing inhibitor, such as tamoxifen, NVP-231 synergistically increased ceramide levels and reduced cell growth.

物理化学性质&存储条件

分子量	431.55
分子式	C25H25N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide

参考文献

1. Graf C, et al. Mol Pharmacol. 2008 Oct;74(4):925-32.

NVP-231 (NVP231, NVP 231)

生物&药学活性

物理化学性质&存储条件

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NVP-231 (NVP231, NVP 231)

生物&药学活性

物理化学性质&存储条件

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