NVL inhibitor MM17

Chemical Structure : NVL inhibitor MM17

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货号: PC-25301Not For Human Use, Lab Use Only.

NVL inhibitor MM17 is a small molecule inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 0.38 uM, inhibits HCT116 growth in a dose-dependent manner with IC50 of 0.54 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NVL inhibitor MM17 is a small molecule inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 0.38 uM, inhibits HCT116 growth in a dose-dependent manner with IC50 of 0.54 uM.
NVL resistance hotspots, particularly H304R and R403W, is sufficient to confer MM17 resistance.
MM17 inhibits NVL and blocks nucleolar 60S biogenesis, has limited impact on 40S production.
MM17 induces p53 dependent and independent cell cycle arrest in HCT116 cells.

物理化学性质&存储条件

分子量	394.45
分子式	C21H18N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(10-(2-methoxyethyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-7-yl)furan-3-carboxamide

参考文献

1. Guo HH, et al. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667081.