NV-128 |CAS:154447-38-8 Probechem Biochemicals

Chemical Structure : NV-128

CAS No.: 154447-38-8

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NV-128 (NV 128;NV128;LY-303511;LY 303511)

货号: PC-60555Not For Human Use, Lab Use Only.

NV-128 (LY-303511) is a novel isoflavone derivative that inhibits mTOR and promotes caspase-independent cell death.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
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生物&药学活性

NV-128 (LY-303511) is a novel isoflavone derivative that inhibits mTOR and promotes caspase-independent cell death.
NV-128 induce significant cell death in both paclitaxel-resistant and carboplatin-resistant EOC cells with GI50 of 1-5 ug/mL.
NV-128 significantly depresses mitochondrial function by decrease in ATP, Cox-I, and Cox-IV levels, and by increase in mitochondrial superoxide and hydrogen peroxide.

物理化学性质&存储条件

分子量	306.365
分子式	C19H18N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one

参考文献

1. Alvero AB, et al. Cancer. 2009 Jul 15;115(14):3204-16.

2. Alvero AB, et al. Mol Cancer Ther. 2011 Aug;10(8):1385-93.

NV-128 (NV 128;NV128;LY-303511;LY 303511)

生物&药学活性

物理化学性质&存储条件

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NV-128 (NV 128;NV128;LY-303511;LY 303511)

生物&药学活性

物理化学性质&存储条件

参考文献

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