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首页-抗体药物偶连体和PROTACs-PROTAC-NUP214 degrader 0449-b
NUP214 degrader 0449-b

Chemical Structure : NUP214 degrader 0449-b

CAS No.:

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NUP214 degrader 0449-b

货号: PC-27930Not For Human Use, Lab Use Only.

NUP214 degrader 0449-b is a selective nucleoporin NUP214 degrader by recruiting NUP214 to the Cullin5-Rbx2 E3 ligase complex, induces NUP214 neddylation and proteasomal degradation, triggers leukemia stem cells (LSCs) ferroptosis and exhibits anti-leukemic activity, while sparing normal hematopoietic stem cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NUP214 degrader 0449-b is a selective nucleoporin NUP214 degrader by recruiting NUP214 to the Cullin5-Rbx2 E3 ligase complex, induces NUP214 neddylation and proteasomal degradation, triggers leukemia stem cells (LSCs) ferroptosis and exhibits anti-leukemic activity, while sparing normal hematopoietic stem cells.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Zhe Chen, et al. Blood. 2026 Aug 25:blood.2026033244.

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