NU6140 | CDK2 inhibitor | Probechem Biochemicals

Chemical Structure : NU6140

CAS No.: 444723-13-1

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NU6140 (NU-6140)

货号: PC-25728Not For Human Use, Lab Use Only.

NU6140 is a selective inhibitor of CDK2 with IC50 of 0.41 uM for CDK2-cyclin A, 10- to 36-fold selective for CDK2-cyclin A over the other CDKs.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
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生物&药学活性

NU6140 is a selective inhibitor of CDK2 with IC50 of 0.41 uM for CDK2-cyclin A, 10- to 36-fold selective for CDK2-cyclin A over the other CDKs.
NU6140 inhibits cell proliferation and cell cycle progression and potentiates the apoptotic response to paclitaxel in HeLa cells in comparison with purvalanol A.
NU6140 significantly increases the apoptotic rate (to a greater extent than that observed in the paclitaxel-purvalanol A combination), with inhibition of survivin expression/phosphorylation in combination with paclitaxel.

物理化学性质&存储条件

分子量	422.53
分子式	C23H30N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide

参考文献

1. Pennati M, et al. Mol Cancer Ther. 2005 Sep;4(9):1328-37.

2. Bhattacharya S, et al. Apoptosis. 2014 Mar;19(3):451-66.

NU6140 (NU-6140)

生物&药学活性

物理化学性质&存储条件

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NU6140 (NU-6140)

生物&药学活性

物理化学性质&存储条件

参考文献

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