NU6102 |CAS:444722-95-6 Probechem Biochemicals

Chemical Structure : NU6102

CAS No.: 444722-95-6

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NU6102 (NU-6102;NU 6102)

货号: PC-70115Not For Human Use, Lab Use Only.

NU6102 is a potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

NU6102 is a potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
NU6102 exhibits synergistic growth inhibition, and enhanced cytotoxicity in HT29 cells in vitro and HT29 tumour growth inhibition in vivo combined with Pictilisib.
NU6102 induces G2 arrest, inhibition of Rb phosphorylation and cytotoxicity in SKUT-1B cells (LC50=2.6 uM, for a 24h exposure).

物理化学性质&存储条件

分子量	402.5
分子式	C18H22N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((3R,6S,9S,12R)-6-ethyl-9-(3-guanidinopropyl)-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclohexadecan-12-yl)isobutyramide

参考文献

1. Hardcastle IR, et al. J Med Chem. 2004 Jul 15;47(15):3710-22.

2. Beale G, et al. Br J Cancer. 2016 Sep 6;115(6):682-90.

3. Thomas HD, et al. Eur J Cancer. 2011 Sep;47(13):2052-9.

NU6102 (NU-6102;NU 6102)

生物&药学活性

物理化学性质&存储条件

参考文献

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NU6102 (NU-6102;NU 6102)

生物&药学活性

物理化学性质&存储条件

参考文献

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