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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-NU1025
NU1025

Chemical Structure : NU1025

CAS No.: 90417-38-2

NU1025 (NU-1025)

货号: PC-26674Not For Human Use, Lab Use Only.

NU1025 is a potent PARP inhibitor with IC50 of 400 nM and Ki of 48 nM, potentiates the cytotoxicity of ionizing radiation and anticancer agents, shows anti-cancer and neuroprotective activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NU1025 is a potent PARP inhibitor with IC50 of 400 nM and Ki of 48 nM, potentiates the cytotoxicity of ionizing radiation and anticancer agents, shows anti-cancer and neuroprotective activity.

物理化学性质&存储条件

分子量 176.18
分子式 C9H8N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

8-Hydroxy-2-methylquinazolin-4(3H)-one

参考文献

1. Boulton S, et al. Br J Cancer. 1995 Oct;72(4):849-56.

2. Bowman KJ, et al. Br J Cancer. 1998 Nov;78(10):1269-77.

3. Griffin RJ, et al. J Med Chem. 1998 Dec 17;41(26):5247-56.

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