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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-NT-0249 free base
NT-0249 free base

Chemical Structure : NT-0249 free base

CAS No.: 2763617-38-3

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NT-0249 free base (NT0249)

货号: PC-25503Not For Human Use, Lab Use Only.

NT-0249 free base is a potent,  specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.

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5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NT-0249 free base is a potent,  specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
NT-0249 potently blocked (LPS + ATP)-induced IL-1β release with IC50 of 12 nM.
NT-0249 curtails systemic inflammation and astrogliosis in preestablished obese states in mice.

物理化学性质&存储条件

分子量 459.57
分子式 C22H29N5O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Urea, N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-N′-[[(1-methyl-1H-pyrazol-4-yl)[[(2S)-tetrahydro-2-furanyl]methyl]amino]sulfonyl]-

参考文献

1. Thornton P, et al. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826.

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