NSYSU-115 | RSK2 inhibitor | Probechem Biochemicals

Chemical Structure : NSYSU-115

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NSYSU-115 (NSYSU115)

货号: PC-25304Not For Human Use, Lab Use Only.

NSYSU-115 is a highly potent, selective RSK2 inhibitor with IC50 of 45.5 nM.

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生物&药学活性

NSYSU-115 is a highly potent, selective RSK2 inhibitor with IC50 of 45.5 nM.
NSYSU-115 exhibited exceptional inhibitory effects on RSK2 in a panel of 41 kinases from various human kinome families.
NSYSU-115 reduces cell viability in AsPC-1 cells, with decreases of 11%, 14.3%, 17.4%, and 48.2% at concentrations of 1, 3, 10, and 30 μM, respectively.
NSYSU-115 (0.3 uM) induces significant effects in MIA PaCa-2 cells, NSYSU-115 demonstrates a dose-dependent inhibitory effect on colony formation in the pancreatic cancer cell lines.
NSYSU-115 inhibits phosphorylation and degradation downstream of RSK2 in pancreatic cancer cell lines.
NSYSU-115 exhibits a significant inhibitory effect on vimentin expression in pancreatic cancer cell lines.

物理化学性质&存储条件

分子量	270.25
分子式	C13H10N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-hydroxy-6-methyl-3-(3-oxo-2,3-dihydro-1,2,4-triazin-6-yl)quinolin-2(1H)-one

参考文献

1. Chung CH, et al. J Enzyme Inhib Med Chem. 2025 Dec;40(1):2538673.

NSYSU-115 (NSYSU115)

生物&药学活性

物理化学性质&存储条件

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NSYSU-115 (NSYSU115)

生物&药学活性

物理化学性质&存储条件

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