NSP-513 | PDE3 inhibitor | Probechem Biochemicals

Chemical Structure : NSP-513

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NSP-513 (NSP513)

货号: PC-25902Not For Human Use, Lab Use Only.

NSP-513 is a potent and selective phosphodiesterase 3 (PDE 3) inhibitor, shows antiplatelet, antithrombotic, and hemodynamic effects.

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生物&药学活性

NSP-513 is a potent and selective phosphodiesterase 3 (PDE 3) inhibitor, shows antiplatelet, antithrombotic, and hemodynamic effects.
NSP-513 potently inhibits collagen-induced canine platelet aggregation with IC50 of 93 nM.
NSP-513 inhibits adenosine diphosphate (ADP)-induced canine platelet aggregation with IC50 of 0.15 uM.
NSP-513 decreases ADP-induced platelet aggregation, the presence of prostaglandin E1 (PGE1; 3 and 10 nM), with IC50 of 0.15 uM.
Orally administered NSP-513 (0.03-1 mg/kg) inhibited collagen-induced canine platelet aggregation in ex vivo antiplatelet aggregation studies.
Intraduodenally administered NSP-513 (0.01-0.03 mg/ kg) dose-dependently prevented thrombus formation without any changes in blood pressure, heart rate, or bleeding time.

物理化学性质&存储条件

分子量	339.44
分子式	C20H25N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-methyl-6-(4-((3-oxo-2-propylcyclohex-1-en-1-yl)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one

参考文献

1. Hirose H, et al. J Cardiovasc Pharmacol. 2000 Apr;35(4):586-94.

NSP-513 (NSP513)

生物&药学活性

物理化学性质&存储条件

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NSP-513 (NSP513)

生物&药学活性

物理化学性质&存储条件

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