NSH76 | RNA Pol I inhibitor, RRN3 inhibitor | Probechem Biochemicals

Chemical Structure : NSH76

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NSH76 (NSH-76)

货号: PC-25714Not For Human Use, Lab Use Only.

NSH76 is a potent and selective RNA polymerase I (Pol I) inhibitor, inhibits Pol I-specific transcription initiation factor RRN3, selectively inhibits Pol I transcription by disrupting the Pol I pre-initiation complex.

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生物&药学活性

NSH76 is a potent and selective RNA polymerase I (Pol I) inhibitor, inhibits Pol I-specific transcription initiation factor RRN3, selectively inhibits Pol I transcription by disrupting the Pol I pre-initiation complex.
NSH76 specifically binds to RRN3.
NSH76 selectively inhibits Pol I transcription in cancer cells, effectively suppresses rRNA synthesis, disrupts PIC formation, and induces nucleolar stress, in RRN3-high cancer cells.
NSH76 does not affect cMyc expression, a Pol II-driven transcript, confirming its specificity.
NSH76 induces anti-proliferative effects via p53 activation, cell cycle arrest, and apoptosis, with IC50 of 7.52, 3.73, and 4.04 µM in A549, PC3, and MCF7 cell lines.
NSH76 enhances cisplatin and doxorubicin sensitivity in resistant cells.

物理化学性质&存储条件

分子量	322.82
分子式	C13H15ClN6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-amidino-2-thiourea-alkyl-7-chloroquinoline-4-amine)

参考文献

1. Sarkar SS, et al. J Transl Med. 2025 Oct 20;23(1):1131.

NSH76 (NSH-76)

生物&药学活性

物理化学性质&存储条件

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NSH76 (NSH-76)

生物&药学活性

物理化学性质&存储条件

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