NSC146109 (XI-011)

Chemical Structure : NSC146109

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货号: PC-21746Not For Human Use, Lab Use Only.

NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.

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生物&药学活性

NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.
NSC146109 (XI-011) activates p53 by increasing its stability, significantly extends the half-life of p53.
NSC146109 (XI-011) (0.5 uM) induces apoptosis in breast cancer cell MCF-7.
NSC146109 (XI-011) inhibits MDMX gene transcription, decreases the viability of breast cancer cells expressing a low level of MDMX in a less-efficient manner.
NSC146109 (XI-011) decreases the viability of breast cancer cells in collaboration with Nutlin-3a.

物理化学性质&存储条件

分子量	280.39
分子式	C17H16N2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(10-methylanthracen-9-yl)methyl carbamimidothioate

参考文献

1. Hongbo Wang, et al. Neoplasia. 2011 Jul;13(7):611-9.

NSC146109 (XI-011)

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物理化学性质&存储条件

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NSC146109 (XI-011)

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