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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Filovirus-NSC135618
NSC135618

Chemical Structure : NSC135618

CAS No.: 2253964-26-8

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NSC135618

货号: PC-25591Not For Human Use, Lab Use Only.

NSC135618 is a potent, allosteric inhibitor of the flavivirus NS2B-NS3 protease, inhibits the protease of Dengue virus 2 (DENV2) in vitro with IC50 of 1.8 uM, shows broad spectrum flavivirus protease, inhibits DENV2, Zika virus (ZIKV), West Nile virus (WNV), and Yellow fever virus (YFV) on A549 cells in vivo with EC50 in low micromolar range.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NSC135618 is a potent, allosteric inhibitor of the flavivirus NS2B-NS3 protease, inhibits the protease of Dengue virus 2 (DENV2) in vitro with IC50 of 1.8 uM, shows broad spectrum flavivirus protease, inhibits DENV2, Zika virus (ZIKV), West Nile virus (WNV), and Yellow fever virus (YFV) on A549 cells in vivo with EC50 in low micromolar range.

物理化学性质&存储条件

分子量 431.23
分子式 C19H12Cl2N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-(2-chloro-4-nitrophenyl)hydrazineylidene)-N-(3-chlorophenyl)-6-oxocyclohexa-1,4-diene-1-carboxamide

参考文献

1. Brecher M, et al. PLoS Pathog. 2017 May 25;13(5):e1006411.

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