NSC126405 | DEPTOR inhibitor | Probechem Biochemicals

Chemical Structure : NSC126405

CAS No.: 17581-52-1

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NSC126405 (NSC 126405)

货号: PC-27310Not For Human Use, Lab Use Only.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

NSC126405 is a small-molecule DEPTOR inhibitor that prevent DEPTOR binding to mTOR, acutely activates mTORC1 and selectively induces MM cell apoptosis and cell cycle arrest, binds to recombinant DEPTOR but not mTOR.
NSC126405 prevents mTOR/DEPTOR binding within MM cell lines and SPR assays.
NSC126405 cytotoxic effect against MM cell lines with the highest DEPTOR expression with IC50 of 0.8-2.5 uM.
NSC126405 induces apoptosis and cell-cycle arrest in multiple myeloma cell lines and prevents outgrowth of human multiple myeloma cells in immunodeficient mice.

物理化学性质&存储条件

分子量	231.89
分子式	C5H2Cl4N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2,3,4,5-tetrachloro-1-cyclopenta-2,4-dienylidene)hydrazine

参考文献

1. Shi Y, et al. Cancer Res. 2016 Oct 1;76(19):5822-5831.

NSC126405 (NSC 126405)

生物&药学活性

物理化学性质&存储条件

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NSC126405 (NSC 126405)

生物&药学活性

物理化学性质&存储条件

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