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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-NSC117079
NSC117079

Chemical Structure : NSC117079

CAS No.: 500363-63-3

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NSC117079 (NSC-117079, NSC 117079)

货号: PC-60664Not For Human Use, Lab Use Only.

NSC117079 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3580 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC117079 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
NSC117079 also inhibits PHLPP2, has no activities against other phosphatases.
NSC117079 activated AKT and ameliorates staurosporine-induced cell death in neurons.

物理化学性质&存储条件

分子量 473.474
分子式 C20H15N3O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-amino-9,10-dioxo-4-((3-sulfamoylphenyl)amino)-9,10-dihydroanthracene-2-sulfonic acid

参考文献

1. Jackson TC, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.

2. Sierecki E, et al. J Med Chem. 2010 Oct 14;53(19):6899-911.

3. Hwang SM, et al. J Orthop Res. 2017 Oct 25. doi: 10.1002/jor.23781.

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