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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-NRL-1049 dihydrochloride
NRL-1049 dihydrochloride

Chemical Structure : NRL-1049 dihydrochloride

CAS No.: 1973494-17-5

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NRL-1049 dihydrochloride (BA-1049)

货号: PC-27868Not For Human Use, Lab Use Only.

NRL-1049 dihydrochloride ((R)-BA-1049) is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NRL-1049 dihydrochloride ((R)-BA-1049) is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.
Neither BA-1049 nor the metabolite inhibits PKA or PKC at physiological ATP concentrations.
BA-1049 is a promising drug candidate to reduce lesion growth and hemorrhage in both CCM1 and CCM3 models of cavernous angioma (CA).

物理化学性质&存储条件

分子量 392.34
分子式 C16H23Cl2N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-1-(1-(Isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine dihydrochloride

参考文献

1. Lisa McKerracher, et al. Transl Stroke Res. 2020 Jun;11(3):365-376.

2. Patent US20170313680A1.

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