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首页-小分子抑制剂&激动剂-Others-Mitochondrial Permeability Transition Pore (mPTP)-NRG1271
NRG1271

Chemical Structure : NRG1271

CAS No.: 3077720-24-9

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NRG1271 (NRG-1271)

货号: PC-26751Not For Human Use, Lab Use Only.

NRG1271 is an orally bioavailable, brain-penetrant mitochondrial permeability transition pore (mPTP) inhibitor, prevent the mitochondrial gain-of-function toxicity of misfolded TDP-43 and α-synuclein.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NRG1271 is an orally bioavailable, brain-penetrant mitochondrial permeability transition pore (mPTP) inhibitor, prevent the mitochondrial gain-of-function toxicity of misfolded TDP-43 and α-synuclein.

物理化学性质&存储条件

分子量 346.31
分子式 C17H13F3N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-2-Fluoro-3-(7-fluoro-1H-indazol-6-yl)-N-(5-fluoro-2,4-dimethylpyridin-3-yl)acrylamide

参考文献

1. Patent WO2025052129 A1.

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