NR162 | CASK inhibitor | Probechem Biochemicals

Chemical Structure : NR162

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NR162 (CASK inhibitor)

货号: PC-72703Not For Human Use, Lab Use Only.

NR162 is a specific small molecule inhibitor of CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) with IC50 of 0.08 uM, and ITC binding Kd of 22 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NR162 is a specific small molecule inhibitor of CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) with IC50 of 0.08 uM, and ITC binding Kd of 22 nM.

NR162 has no effect of 26 on cellular growth or toxicity at 10 uM against NCI60 panel of cancer cell lines.

NR162 shows littile to no activity against TYRO3, MERTK, AXL, ABL1 and CSNK1E

NR162 is a potent and highly selective tool compound studying the diverse functions of CASK as well as exploring its potential as a possible target for pharmaceutical intervention.

物理化学性质&存储条件

分子量	610.351
分子式	C24H30Br2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide

参考文献

1. Nadine Russ, et al. J Med Chem. 2021 Oct 14;64(19):14358-14376.